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Gout - Information and Resources About Gout Treatment

Gout is a painful and potentially disabling rheumatic disease and is one of the most common forms of arthritis. Gout accounts for approximately 5% of all cases of arthritis. Gout usually affects the first metatarsal phalangeal joint of the big toe (hallux) or the ankle joints. Gout most often affects the big toe but can also affect the ankle, knee, foot, hand, wrist and elbow. Approximately one million people in the United States suffer from attacks of gout. Gout is nine times more common in men than in women. It predominantly attacks males after puberty, with a peak age of 75. In women, gout attacks usually occur after menopause.


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It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

Gout is a problem that definitely needs treatment. Many ways of easing the pain or avoiding the severe attacks are known. Doctors recommend the patients in most of the cases good rest and to increase the amount of fluids that they drink. This is recommended for the easy forms of gout. Acute gout has to be treated with medicine therapy in order to decrease the pain and inflammations in the joints. The drugs usually prescribed for acute gout are non-steroidal anti inflammatory drugs (NSAIDs) such as indomethacin, ketoprofen, oxaprozin, diclofenac, ibuprofen and others.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

Gout attacks occur suddenly in most of the cases. The first attack is surely going to develop at night, people getting to wake up feeling an extreme joint pain. During gout attack people usually develop the following symptoms: sudden and severe joint pain, swelling, reddish skin around the affected joints and extreme sensitivity in those areas.

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

Excessive alcohol consumption increases uric acid levels in the blood since alcohol disrupts the disposal of uric acid from the body. Diuretics, which are medications prescribed to help dispose of excess body fluids resulting from certain diseases like hypertension, edema, and other cardiovascular diseases.

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

Reduce calorie intake to maintain a healthy weight. However, avoid fad diets or very low calorie diets as rapid weight loss can precipitate gout.

In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

Purines are mostly found in foods which are high in protein and fat content. Vegetable oils, greasy burgers and fatty fish are all high in purines, so you should avoid fried foods and naturally fatty produce. Basically, high purine content is found in almost all kinds of food: pork, beef, chicken, turkey, salmon, tuna, oysters, scallops, creams, eggs, peas and beans. But there are ways to have a low-purine diet.

Cherries and strawberries have shown to have a particular helpful effect on gout so these foods should be eaten every day on the anti-gout diet for the prevention of gout.

A low-purine diet and medications are commonly used to treat gout. Purines are mostly found in foods which are high in protein and fat content. For breakfast, take low-fat protein foods. High-protein foods that are low in fat have been found to be safe.

To prevent future attacks, your doctor can prescribe a medicine to reduce uric acid buildup in your blood. Changing the way you eat can help you conduct your gout. Eat a healthy mix of foods so you get the nutrients you need. Limit foods like meat, fish, and beer. Drink plenty of water and other fluids.Life style changes such as limiting alcohol consumption, and limiting meals with meats and fish rich in purines can also be helpful in controlling gout. Weight loss may be very important this condition. You should also avoid certain animal proteins, such as: seafood; liver; kidney; heart; gizzard; sweetbreads; meat extracts; and gravy.

Alcohol and certain foods can trigger a gout attack. Events such as strokes, heart attacks or surgery may also cause gout. Gout is strongly associated with obesity, hypertension, hyperlipidemia and diabetes. Because of genetic factors, gout tends to run in some families. A variety of treatments can help you manage your gout. Traditionally treatment for acute gout has consisted of colchicine , which can be effective if given early in the attack. Gout often is treated with nonsteroidal anti-inflammatories (NSAIDs) such as naproxen (e.g., Anaprox, Naprosyn) and indomethacin (e.g., Indocin), usually for 3-7 days.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

Consume a moderate amount of protein. Limit meat, fish and poultry to 4 - 6 oz per day. Try other low-purine good protein foods such as low fat dairy products, tofu and eggs.

Drink several glasses of water everyday. 8-10 glasses daily is ideal. Water dilutes uric acid (a cause of gout) and rids them from the body. Cloudy urine means you have high acid content in your body and this is not a healthy sign. Clear urine suggests that you are properly hydrated and well on your way to good health.

Most fruits and vegetables are high in potassium. Potassium regulates electrolytes in the body and has the ability to get rid of uric acid crystals from the blood. Potassium-rich fruits are bananas, avocados, apricots and cantaloupe. High-potassium vegetables include spinach, potatoes, asparagus, beets and pumpkin.

Colchicine is also used because it eases the pain cause by gout. The problem with this medicine it's its side effects that can not be tolerated by any patient. Its side effects include diarrhea, nausea, vomiting and abdominal cramps.

Gout Symptoms The most common gout symptom is sudden, severe attacks of pain, tenderness, redness, warmth and swelling in some joints. It usually affects one joint at a time, especially the joint of the big toe, but can also affect the knee, ankle, foot, hand, wrist and elbow. Deposits of uric acid, called tophi, can appear as lumps under the skin around the joints and at the rim of the ear. In addition, uric acid crystals can also collect in the kidneys and cause kidney stones.

 
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Diagnosis A definitive diagnosis of gout is from light microscopy of fluid aspirated from the joints (this test may be difficult to perform) to demonstrate intracellular monosodium urate crystals in synovial fluid polymorphonuclear leukocytes. The urate crystal is identified by strong negative birefringence under polarised microscopy and its needle-like morphology. A trained observer does better in distinguishing them from other crystals.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.

Include lemon juice at lunch for cleansing. Lemon juice is filled with vitamin C and antioxidants to help flush your body from unwanted uric acids. Couple the drink with a hearty salad and meal using tofu to replace red meat or chicken, finely chopped fresh garlic and extra virgin olive oil.

Gout symptoms occur in three phases. The first phase refers to the sudden onset of a joint pain, especially in the big toe, that lasts more than 5 days, going in some cases up to 10 days or even more. The second period is believed to be a period with no symptoms or attacks. This is the period between episodes. The third phase refers to the untreated cases of gout. In this last phase persistent symptoms develop. During this phase episodes occur more often and cause severe pain.

Zone dieting definitely works, people testify to that fact. Many have felt increased body and mind energy levels after only a week with it. Even those with existing medical conditions have seen an improvement in their physical wellbeing. This program is not a weight loss strategy, it is a health strategy. Watch the food you eat and watch the lifestyle you live. Do that, and better yet, let zone diet help do that for you.

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.

Corticosteroids are also used but not as often as NSAIDs or colchicine because they do not have the same effect. Chronic gout is usually treated with xanthine oxidase inhibitors or uricosuric agents that help the kidneys to eliminate the excess of uric acid produced in the body.

In the beginning of the disease rare episodes are happening. In that phase episodes do not last a long period of time. More than that after an episode everything seems to be going back to normal and between episodes no symptoms occur. It is recommended for the disease to be treated with medication in order to prevent the more often occurrence of these episodes. If gout is not treated the episodes might last longer and might occur more often too. The repeating episodes might lead to a damage of the affected joints, causing limited mobility after any attack.

All these symptoms might be a cause of an unhealthy diet or even the cause of too much alcohol drinking. Beside these factors that may lead to gout we also need to mention that gout may occur after a surgical intervention, after a sudden and severe illness or after chemotherapy. An injury to a joint might also lead to development of gout.

Beneficial Dietary Supplements: * Bromelain reduces inflammation in joints and improves digestion of proteins when taken with meals, * Vitamin B Complex aids digestion and supports the body's enzyme systems.

Read about Herbal Remedies, Natural Remedies. Also read about Breast Enlargement and Breast Enhancement and Dogs Cats Health, Pets Health Guide

* Vitamin C with Bioflavinoids lowers serum uric acid levels.

Juice one small or half a medium-sized beet root, greens and all. Add a quarter bitter gourd, cut length-wise. This juice is very potent and should not be taken too frequently, especially if you are not accustomed to beet. Take it only once, or twice a week at the most.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.

SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

For more information about gout treatments please review http://www.gout-info-center.com/gout-symptoms.htm or even http://www.gout-info-center.com/gout-treatments.htm


 
 
     
 
 





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