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Interesting Facts about Arthritis

What exactly is arthritis? The term arthritis literally means joint inflammation, but it also is used to refer to more than 100 rheumatic diseases. These diseases can cause pain, stiffness, and swelling in joints and may also affect other parts of the body. Some common types of arthritis are osteoarthritis, rheumatoid arthritis, systemic lupus erythematosus, gout, juvenile rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis.


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Remember when you could sleep the whole night without a flare-up of gout? Do you remember what it was like to not have to wince with pain when you walk? Fortunately, gout is treatable and curable and these 6 suggestions will get you on the right path to treat your gout symptoms.

5 Tips to Treat Your Gout 1. Find a pair of shoes that fit comfortably. Try finding a wider shoe that will offer more room for your toe.

Colchicine is typically used if the first line medications like NSAID's do not help but most people have relief of pain ultimately. Even if no medicines are taken the attack will subside in a few days. However if repeated attacks occur there can be lasting damage.

How Gout Works Gout is characterized with excruciating pain in the joint at the base of the big toe. In fact, about three-quarters of gout sufferers suffer from this excruciating pain affecting the toe. The other areas of the body gout might affect include: the elbows, shoulders, hands, wrists, knees and feet. The gout sufferer's joints will become swollen and inflamed and a fever could also develop. Most often, gout symptoms can last for days (2-5 days). Simply stated, gout is caused by higher levels of uric acid in the blood. There are several reasons for this happening including: overweight, too little activity, too much alcohol, various medications, genetics, or even a health disease (hypertension, etc). Whatever the cause, you can cure your gout if you begin your treatment today!

Approval in one country does not mean approval in another, but the fact that the European Medicines Agency has approved it will carry weight when the medical authorities in other countries consider its approval.

The relief of pain is remarkable with some of the anti-inflammatory medicines also called NSAIDS or non-steroidal anti-inflammatory medications. The typical example is indomethacin or ibuprofen. Applying local ice or heat may sometimes help as well as keeping the joint without moving or bumping into objects.

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BENEFITS In large trials Febuxostat (Adenuric) has outperformed Allopurinol, the most common gout medication for long term treatment. Like Allopurinol, it works to lower uric acid production by inhibiting xanthine oxidase, an enzyme required to produce uric acid. In two major studies it reduced uric acid (UA) in more gout sufferers, and more patients reached the target 6.0 mg/dL level more quickly, than did those on Allopurinol.

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This approval applies only to EU countries. Febuxostat has not yet been approved in the United States. If you are reading this from a non-EU country, or the US, you can check with your doctor to find out whether, or when, Febuxostat will be approved in your country.

At 120 mg it has reduced UA levels to the target of 6.0 mg/dL in over 60% of study patients. At 80 mg the numbers were around 51%. Allopurinol at a 300 mg dosage in most participants achieved this is 22% of study patients. Hence the excited buzz in rheumatology circles since these kinds of results became apparent in its trials. At or below 6.0 mg/dL gout is more likely to be cured or managed better.

It is recommended that NSAIDs or Colchicine are used along with Adenuric. This is because, as with Allopurinol, on a course of Febuxostat, there may be an initial increase in gout flares. If this happens you must battle through the attacks and continue taking Adenuric.

It has taken a very long time for a major new gout drug to be developed and approved. Probably the best gout news in over 40 years, is that Febuxostat, which has been given the trade/brand name of Adenuric, has been approved by the European Medicines Agency for marketing in European Union (EU) countries.

Does arthritis affect more women than men? Rhemathoid arthritis is two to three times more common in women than men. Men, however, are at greater risk than women of developing gout.

IT'S NOT PERFECT In trials its success rate in reducing UA levels down to the important 6.0 mg/dL (357 mmol/??mol) level was not 100%. About 35% of trial patients did not achieve the target. This may have been partly because so many gout sufferers are not UA over-producers, the problem Febuxostat addresses, but under-excretors of uric acid.

If a person is on many medications, which can cause gout, changing these may help. One common cause is diuretic medications, which decrease leg swelling or edema. Many older individuals are on these medicines and if they get a gout attack they must remember this fact.

When does arthritis appear? Rheumatoid arthritis -- one of the many forms of arthritis -- typically begins at 20 to 50 years of age, although it can develop in childhood.

If you have severe kidney or liver problems Febuxostat is not recommended since it has not been tested in these patient groups. It is not recommended for people with heart disease or children.

Gout is caused by the increase in the amount of uric acid in the blood. Uric acid is normally removed from the body through the urine, however if it is not excreted it can form crystals, which irritate body tissues like the lining of joints. This will in turn cause inflammation and pain, which is often quite severe.

In some situations steroid medications like prednisone may be needed. The steroids will decrease the inflammation and decrease the chemical responses that cause pain. It is important to know that there are many side effects from all of the medications and you must discuss these with your healthcare provider.

 
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"week ago i couldnt walk and was in terible pain. i though my big toe was broken i would need a surgery, but doctor said it was gout. After taking some pain killer and goutezol for 2 days i can walk again. thank you" Peter from Chicago
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What kind of cause can trigger arthritis? While genes appear to be a contributing factor to arthritis, there are other causes. Researchers believe that environmental agents -- a virus, or even stress, can trigger the disease in people who are genetically predisposed to it.

2. Keep your toe elevated when resting/sleeping. Allow gravity to reduce the inflammation on the gout inflicted joint. 3. Try to stay off the joint with gout. Any pressure exerted on the area will cause more pain and further damage to the area.

You will not need to be on a low purine diet, and more good news is that it can be prescribed for the elderly. Kidney and liver disease In trials it has performed quite well with patients who have mild kidney disease. 44% of patients achieved the target at an 80 mg dosage, more at higher dosages. Better results than Allopurinol. If you have mild kidney disease (renal impairment) or mild liver problems (hepatic impairment) your doctor will judge whether Adenuric/Febuxostat can be taken safely.

Noted possible side effects dizziness, drowsiness, diarrhoea, rashes, headaches, hypertension and liver function abnormalities - considered mild ones. In trials none of these side effects were reported in more than 3.5% of trial patients. The most common were liver function abnormalities.

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And it may cause side effects of course. See the bottom of this article. Febuxostat (Adenuric) is not unfortunately a treatment for gout pain. It won't be used instead of NSAIDS like Indomethacin, Colchicine, and corticosteroids.

How many Amercians suffer from chronic symptoms of arthritis? 40 million! Are there several forms of arthritis? Yes, there are more than one hundred forms of arthritis and the causes of many are unclear. The two most common forms of arthritis are osteoarthritis (commonly referred to as simply arthritis) and rheumatoid arthritis. Gout is a less common form of the disease.

It will also only be used in gout patients who have chronic hyperuricemia (high UA levels) and gout. So if you're a gout sufferer who lives in a European country that's a member of the EU, you can ask your doctor's opinion about whether Febuxostat is suitable for you.

4. Avoid ice and heat. Unlike other types of pain, gout will often hurt more with exposure to heat or ice. 5. Drink water! Water will help the body flush excess uric acid thus decreasing your chance of gout. Drink 10-12 glasses of water per day.

WHO WILL BE PRESCRIBED IT? The recommended dose is one 80 mg daily tablet. If after two weeks there is no reduction in UA levels, your doctor may increase the dose to 120 mg daily. Patients will need another serum UA test after two weeks treatment to find out how well it's doing. In trials it has usually worked quickly, within a couple of weeks.

NB. The contents of this article contain medical information not medical advice. Please always discuss remedies with your doctor or other health care professional, before implementing any treatment.

As with all medications make sure you do not have an allergy to them and sometimes taking the medicine with food may decrease stomach upset or gastric distress, especially medicines like steroids.

Generally, Febuxostat has been more effective when UA levels are below 10.0 mg/dL (595 mmol/??mol). However, even if they have been above this level, it has reduced UA levels down to the target in about 40% of study patients at an 80 mg dosage, and by more at higher dosages.

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Tophi If you have tophi, it's heartening to know that Febuxostat has been shown to have success against tophi. Measured tophi areas reduced in many patients with tophi. The presence of tophi will be an additional factor in favour of a decision to prescribe Febuxostat (Adenuric).

Your uric acid levels will have to be high. If you have gout but normal or slightly raised uric acid levels as some do, it is unlikely to be prescribed.

In some gout attacks patients may need joint fluid removed for analysis and during the process can have local numbing medicines injected into the joint. These numbing medicines are also called local anesthetics. Sometimes steroids are injected into a joint to decrease the inflammation.

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Gout is a common disease and often presents suddenly with a painful joint. The most common and well-recognized symptom is swelling of the joint in the big toe where it joins the foot. This can be extremely painful and enlarged and if not treated the pain will last about 10 days and can cause lasting damage with repeated attacks. The area can be red, hot, inflamed and very painful or tender....


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Gout is a condition that results when crystals of uric acid are deposited body tissues, and is characterized by an overload of this acid. It causes joints to become inflamed and is often very painful. Chronic gout can lead to deposits of hard lumps in and around the joints. As a result, patients with gout can experience decreased kidney function and kidney stones, which are also very...


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