black colored kidney stones - Things to know about gout
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Things to know about gout

Gout is a fairly old disease, being around for more than two thousand years. Gout is a disease that affects mostly mean, but women can suffer from gout as well, mostly after menopause. Gout is a very hard rheumatic disease, but out off all this type of diseases, gout probably has the best treatment.


In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.


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 - Hip disorders - May cause you to feel pain in the knee area. - Osteoarthritis - a condition affecting the joints characterized by pain and stiffness

- Apply ice 15 minutes at a time, initially and then about 4 times a day thereafter until the pain subsides. - Rest and avoid the activities that contributed to the initial injury

- Tendonitis - Pain that occurs in the front of the knee. It usually gets worse when going up and down stairs. This is a common injury of skiers, runners and cyclists.

Considering that until this study, gout sufferers had been discouraged from drinking coffee, many gout sufferers may now be wondering what other gout and diet prevention beliefs may soon turn out to be disproved. For example, though tea has not been found to reduce uric acid levels in the body as has now been demonstrated with coffee, tea is often thought to be unacceptable as a part of a gout and diet prevention strategy. Instead, tea can indeed be a part of a gout diet as long as it is consumed in moderation and as long as its dehydrating effect is compensated for by taking in additional water.

There was a myth that said that the cause of gout is too much food and drinks. Nowadays, this myth has proven wrong. However, everybody knows that there is a little truth in every myth. This gout myth makes no exception. If you drink a lot, but mainly wine or beer and if you eat more than you should, then gout attacks are more likely to appear. However, this is not the cause of gout. Studies have shown that people who suffer from gout suffer from a chemical process disorder of their bodies. One of the gout causes can be the build up of urate, that can form crystals in your joints. These are very painful. However, this problem is mostly genetic and almost all people who suffer from it inherited gout from their grandparents or parents. Actually, gout is a family problem.

- Get good fitting shoes. When shoes fit poorly we may compensate in the knees and hips, causing them to be misaligned and making them prone to injury.

In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

Even if an injury is the most common cause of a gout attack, illness, fatigue or worry can also trigger a gout attack. If you have an operation, this might also bring an attack of gout just a few days later.

It was also believed at one time that eating rich foods was the root cause of gout. Indeed, some rich foods are high in proteins and purines and therefore may contribute to gout flare-ups, however low fat dairy products have now been shown to have a preventative effect. Also Gout is believed to be caused by many factors, including being heredity.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

Urate is the main cause of gout as studies have shown. However, not all people who have high urate levels actually suffer from gout. Even relatives of gout patients can have high urate levels in their blood and still not suffer from gout or have any gout attack in their lives. Diuretics, that are mainly used to treat high pressures of blood or heart problems can increase the levels of urate and thus lead to gout.

The good news about knee pain is that it responds well to self care measures. There are a number of factors that can put you at risk for knee pain. Some of them are:

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

- Gout - A metabolic disorder caused by an accumulation of uric acid in the joints. As mentioned above knee pain responds well to self care. Some of the things that you can do if you experience knee pain are:

If you follow the above suggestions you will go a long way to
knockout knee pain before it begins.

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A similar belief was once applied to alcohol. It was thought that spirits, wine, and beer were the true cause of gout. Indeed, drinking to excess can be harmful to gout sufferers, especially due to the resulting dehydration of the body. Hydration is especially important to gout sufferers as it allows the body to flush the uric acid out of the blood, preventing its buildup as crystals on the joints. However, drinking alcohol is not a direct cause of gout.

Lack of muscle strength: Experts site lack of strength and flexibility as the leading cause of knee injury and pain. Weak or tight muscles offer less support for the knee joint.

Mechanical problems: Having misaligned knees, one leg that is shorter than the other or other structural abnormalities can contribute to knee pain.

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

- Proper supplements: There are supplements that can help the body keep the ligaments and joints lubricated, and actually help rebuild cartilage. Like Phosoplex' is a supplement that is recommended for osteoarthritis and joint pain. It is a powerful, all natural and safe solution for joint lubrication, pain relief and the rebuilding of healthy cartilage.

Some of the most common causes of knee pain are: - Bursitis - An inflammation that comes from pressure on the knee. The pressure may be from repeated overuse, kneeling for long periods of time or other injury.

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.

 
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Age: Some knee related conditions affect young people more often than old, for example Osgood-Schlatter disease or patellar tendonitis. Other conditions such as gout and osteoarthritis tend to occur in older people.

Overuse: An inflammatory response can occur when a repetitive activity, causes a muscle to get fatigued. This inflammatory response can damage surrounding tissue. This can be further compounded when you don't give the knee enough time to fully recover thereby making it prone to re-injury.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.

SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

Gout is very painful. In fact, this disease is the most painful of all rheumatism or arthritis forms. Gout attacks mainly start during night time and the first gout attack sign is pain in your big toe. This toes becomes swollen, extremely red and painful. However, it is sometimes difficult for doctors to tell you if you are having a gout attack or it is just a simple bunion case. Besides this joint, other joints can also be attacked by gout. The elbow, wrist or knee are some of the other places at risk of a gout attack.

- Torn ligaments or cartilage - This injury can cause severe pain and lack of stability of the knee joint. - Strain or Sprain - A minor injury to the ligaments cause by sudden or unnatural twisting.

- Gentle compression, such as with an Ace bandage may reduce swelling and provide support It is not always possible to prevent knee pain but there are some things that you can do to lessen the likelihood that knee problems will occur.

You may first feel it when attempting to bend down to pick a dropped item or possibly you experience it as morning stiffness that you feel when you first get up out of bed. But whenever it hits you knee pain will undoubtedly get your attention.

A similar study in Japan looked into the same concept, but used decaffeinated coffee. Similar, though not equal, results were witnessed. This is why it is now thought that components of coffee other than soley caffeine are responsible for lowering the uric acid levels in the body.

It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

Though it is not yet known what part of coffee is responsible for lowering the uric acid levels in the body, it is known that it is not just the caffeine content, as the same results were not found from drinking caffeinated tea. Whatever the cause, when participants drank one to two cups of coffee every day, the levels of uric acid in the blood reduced dramatically. Furthermore, as coffee consumption increased, uric acid levels decreased.

HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

- Exercise wisely. Don't exercise when you have pain or you're tired. If you have chronic injuries consider switching to sports or exercise that put less stress on your joints. For instance swimming instead of basketball.

Recently, a gout and diet prevention study was published in by Dr. Hyon K. Choi and Gary Curhan in Arthritis Care & Research's June 2007 issue which examined the fact that, contrary to popular belief, coffee may not be as bad for gout sufferers as previously thought. Although gout patients have been told to stay away from coffee, there may be an ingredient in the beverage that can actually help to lower the uric acid levels in the body.

An injury to the knee can affect any of the ligaments, tendons Or bursa (fluid filled sacs of the knee)or a combination of these areas of the knee.

- Elevate your knee to bring down the swelling - Over the counter medications can provide pain relieve from pain. - Sleep with a pillow underneath the affected knee

- Keep off excess weight. Maintaining a healthy weight will keep your knees from having to support more than they were designed to support. - Stay flexible. Weak muscles make you more prone to injuries of the knees. So do stretching exercises, daily to maintain flexibility

Overweight: If you weigh more than you should, you put more stress and pressure on your knee joints. Over time this excess pressure can cause pain.

Previous injury: If you have previously injured your knee chances go up that you will injure it again. Possibly because the knee was not given enough time to properly heal or because the knee doesn't return to the condition it was in prior to the injury.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.


It is important to speak with your doctor and dietitian about gout and diet prevention and what you should be eating to help to control your gout. However, it is also wise to keep up with the latest research, as the "truths" that we know about gout diets are always changing.


 
 
     
 
 





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