how is colchicine made - New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
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New Gout Drugs ??? Pegloticase Continues Its Hopeful Path

In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.


Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.


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 Why You Lifestyle is Important Think about a time in your life when you were the healthiest. I can venture to guess that you didn't have gout during that period. And as you get older you might think that gout is a natural process of getting older. You are wrong! But the good news is that you can naturally treat gout with some simple do's and don'ts.

Millions of people search for gout remedies each day hoping to find a way to get rid of the most painful type of arthritis. And most people who succeed in treating gout naturally are able to do so with simple home remedies that involve lifestyle changes.

HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

5 Simple Gout Remedies 1. Flush your body! Most people do not know that they are dehydrated. It is said that 80% of Americans are dehydrated. And research shows that most gout sufferers are in that category. You should be drinking at least 12 tall glasses of water a day if you suffer from this disease. Water flushes the body of uric acid, cholesterol, toxins, plaque, chemicals and many impurities.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

In conclusion, there is some truth in myths, but when it comes to gout, better believe the facts.

If you are intersted in finding more information about gout you can click on this website http://www.gout-info-center.com. Also you will find there valuable information about gout treatments and gout diet.

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But before you run to the doctor and get some painkillers, you might want to try some simple gout remedies that flush uric acid (the cause of gout) and drastically reduce gout attacks.

It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

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4. Vitamins! Studies have all indicated that sufferers usually have a vitamin deficiency. Vitamins A, B5 and E are critical to your diet. These 3 vitamins have been shown to block the formation and advancement of gout symptoms.

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

1. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) - These oral-taken drugs are to provide the patient with relief from the inflammation and pain associated with the arthritis. Unfortunately, NSAIDs will not decrease the amount of uric acid between the joints. Therefore, the NSAIDS will provide relief for a night but will not cure gout.

In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

Get Rid of Gout

Though these traditional treatments will help you cope with the pain and inflammation, the only way to truly get rid of gout is to naturally treat gout with your diet and lifestyle. The following list is a helpful guideline to naturally cure gout.

6. Maintain your ideal body weight. You should know your BMI. 7. Undertake weekly natural health remedies to decrease uric acid levels.

1. Eat healthy foods that include lean fats and high fibers. 2. Eliminate foods with high purines. 3. Drink half your weight in ounces of water per day.

3. Colchicines- Colchicine is an antimitotic that treats acute gout symptoms. Serious side effects include abdominal cramps, diarrhea, nausea, and vomiting.

3. Purines! As stated earlier, purines are a cause of gout. You should moderate your intake of purines immediately. If the body does not have purines to convert to uric acid, you will have fewer and fewer attacks. Here is a list of the high purine foods: red meat products, gravies, shellfish, fish, and dried beans. For a complete food guide, please check out our Gout Remedy Report.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.

Though you might feel like things look bleak, knowing that your diet and some 'changeable' habits caused gout to form, allows you to know how you can get rid of gout naturally through your diet and lifestyle.

Stop dealing with the pain and naturally get rid of gout permanently and never worry about another agonizing night-time attack! Though you might feel like you are alone, gout is one of the oldest documented diseases known to mankind. In fact, gout has been diagnosed for over 2,000 years and is often referred to as the 'disease of kings'.

To be more sure of these facts, here are some useful gout information. First of all, gout is actually another from of arthritis. Crystals are formed in your joints. The main gout target are people whose bodies produce a bigger quantity of uric acid of do not eliminate as much of this acid as they should. So, as you can see, uric acid is the main culprit in a gout case. The most common area for a gout is the joint in your big toe , although all your other joints can be affected by a gout as well.

 
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The science behind gout is the result of needle-like crystals of uric acid that have formed in the body's connective tissue between the two bones. This is usually the byproduct of the body's ability to break down purines from your diet. If the body is unable to eliminate all of the uric acid, the result is a uric acid forming between the joints. And this spells "OUCH"!

As I have said before, the main reason that causes a gout is uric acid in larger quantities than needed. This chemical breaks and builds up food and tissues. Now, you are maybe wondering what causes this uric acid excess. well, to break down the myth, here are some of the main causes: - an increased production of this acid can lead to a gout; - a poor elimination of this acid is also another cause that lead to gout; this poor elimination is cause by your kidneys; - and last eating foods that contain purine; So, as you can see, diet is not the main culprit of a gout, but as in any myth there is some truth, it is one of the causes.

Currently you body is processing too many purines which turn into uric acid. If the blood stream contains too much uric acid, it will form into uric crystals which reside between joints (in most cases the big toe). If gout is not treated by flushing the uric acid, kidney damage will result.

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In the other case, where the myth states that gout can only be treated with medication, let me prove otherwise. Loss of weight can be very beneficial in your gout case. People that have a few extra pounds are more at risk of developing a gout. Furthermore, loosing of weight can relieve your gout symptoms. Changes in your diet can also relieve the gout symptoms and even prevent gout. Try to avoid ant foods containing purine, alcohol and sugar. Cherry juice is also known for preventing a gout attack.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

2. Fiber! You should also eat fiber which causes your body to flush and detoxify itself. Eat at least 7-8 servings of fruits and vegetables a day. Fruits and veggies are high in water soluble fiber which will also flush your attacks away.

Doctors usually prescribe three types of treatments for most gout sufferers. Though the treatments will hide the symptoms, all three treatments are not a permanent solution to cure gout.

Gout is a form of arthritis that has most often been referred to as the most painful. It attacks the joints with a deep, persistent pain. Most often it usually strikes the big toe and it often occurs at night. Most doctors say, "You know that you have gout when your blanket feels like a piece of pavement." Symptoms include extreme pain, swelling, throbbing and heat to the joint of the big toe.

5. Move! Though it might hurt at first you should try to exercise between attacks. Exercise has hundreds of benefits but it also flushes impurities out of your body and keeps your body running efficient. Start with a short 10 minute walk and increase each week.

Anybody who has ever been diagnosed with gout knows that it can be extremely painful. Most people resort to some kind of painkiller which treats the pain but does NOT treat the uric crystals that cause gout. And people who use painkillers tend to damage the joint completely and allow gout to ruin their kidneys and lives.

Naturally Treating Gout Decreases the Chance of another Attack All doctors agree that in order to treat gout completely, you must alter your lifestyle. Here is a small list our natural medical health doctor recommends to all of our customers.

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.

There has always been a battle between myths and facts when it came to gout. This battle has been fought over the cause and treatments of the gout. Some said that your gout can only be treated with medications and gout is caused mainly by your poor diet, whereas others strongly believed otherwise. The fact is that there are many steps that one can take to relieve his/ her gout symptoms and diet is maybe one of the last reasons for developing a gout.

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

Side-effects associated with NSAIDs include bleeding, stomach pain and ulcers. 2. Corticosteroids- Corticosteroids are anti-inflammatory hormones that are injected or taken orally. Though corticosteroids will treat the pain, they will not cure gout or decrease the levels of uric acid between the joints. Side effects for this treatment include bone thinning and a decreased ability for the body to fight against infections.

SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

4. Supplement your diet with a multi-vitamin and the core vitamins. 5. Gradually establish a consistent exercise regimen for body size and age.

Fortunately, gout is a warning sign to tell you that you need to watch what you eat. Your diet could be one thing that could help or hurt your gout symptoms.

Treating Gout after a Hospital Visit Our company has numerous ex-gout sufferers who have seen a doctor, were treated, only to have gout resurface weeks to months later. Unfortunately, traditionally treating gout often does more harm than good because it gives the sufferer false hope.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

We offer the only step by step remedy that is 100% guaranteed for 6 months. Join our thousands of satisfied customers and be gout free by tonight!


 
 
     
 
 





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